Imaging Pearls ❯ PET-CT ❯ Gastric Cancer
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- “Our study showed good specificity of postoperative surveillance (18)F-FDG PET/CT for detecting recurrence. Careful caution should be made for interpreting some false-positive hypermetabolic lesions in postoperative (18)F-FDG PET/CT, especially at the local anastomosis site.”
Performance of (18)F-FDG PET/CT as a postoperative surveillance imaging modality for asymptomatic advanced gastric cancer patients.
Lee DY et al.
Ann Nucl Med. 2014 Oct;28(8):789-95 - “In summary, the limitations of FDG PET and PET/CT in the diagnosis and evaluation of gastric cancer mainly come from three aspects: (1) the variety of histological differences in gastric cancer; (2) the physiological properties of the stomach; and (3) the spatial resolution of PET.”
Diagnosis and evaluation of gastric cancer by positron emission tomography.
Wu CX, Zhu ZH
World J Gastroenterol. 2014 Apr 28;20(16):4574-85 - “Tumor size is one of the major factors influencing the FDG PET detection of primary gastric cancer. For small lesions, PET detection is always a challenge due to its limited spatial resolution. A study showed that FDG PET had a sensitivity of 76.7% for the detection of gastric cancer > 30 mm but only 16.8% for those less than 30 mm. Recent studies have indicated that tumor size was a major factor influencing the standardized uptake value (SUV) of gastric cancer on FDG PET.”
Diagnosis and evaluation of gastric cancer by positron emission tomography.
Wu CX, Zhu ZH
World J Gastroenterol. 2014 Apr 28;20(16):4574-85 - “FDG PET may also have different sensitivities for the detection of different types of gastric malignancies. The biological characteristics vary among different types of gastric malignancies, which may significantly influence the uptake of FDG. Most studies reported that FDG PET had significantly lower sensitivities in detecting diffuse type, mucinous adenocarcinoma (MAC) or signet-ring cell carcinoma (SRC) than the intestinal-type gastric adenocarcinoma or tubular adenocarcinoma (TAC).”
Diagnosis and evaluation of gastric cancer by positron emission tomography.
Wu CX, Zhu ZH
World J Gastroenterol. 2014 Apr 28;20(16):4574-85 - “18F-fluorodeoxyglucose (18F-FDG) as a substrate for tumors with high glucose metabolism has been the most commonly used 18F-FDG-PET radiopharmaceutical in oncologic imaging. However, the usefulness of 18F-FDG-PET in gastric cancer has not yet been fully established. The intent of this review is to help to better understand the impact of 18F-FDG-PET on the imaging of gastric cancer, to offer a greater understanding of how gastric malignancies may present and be recognized on 18F-FDG-PET and to assess the complementary value of PET/CT in gastric cancer staging.
PET/CT findings in gastric cancer: potential advantages and current limitations
Saadet Atay-Rosenthal *, Richard L Wahl & Elliot K Fishman
Imaging in Medicine Vol. 4, No. 2, Pages 241-250
- "The combined use of CT and PET can be helpful in the preoperative staging of stomach cancer and in the therapeutic monitoring of affected patients."
CT and PET in Stomach Cancer: Preoperative Staging and Monitoring of Response to Therapy
Lim JS et al.
RadioGraphics 2006;26:143-156. - "FDG PET may be superior to anatomic imaging modalities in the detection of distant metastases and significant nodal metastases."
CT and PET in Stomach Cancer: Preoperative Staging and Monitoring of Response to Therapy
Lim JS et al.
RadioGraphics 2006;26:143-156. - "Although FDG PET is not an appropriate first line diagnostic procedure in the detection of stomach cancer and is not helpful in tumor staging, it may play a valuable role in the detection of distant metastases."
CT and PET in Stomach Cancer: Preoperative Staging and Monitoring of Response to Therapy
Lim JS et al.
RadioGraphics 2006;26:143-156.