 | Definition and Timing of CIN
Definition of CIN: - An impairment in renal function occurring within 3 days after administration of CM in the absence of an alternative etiology
- Generally defined as an increase in SCr from baseline of ≥25% or ≥0.5 mg/dL (44 μmol/L)
Timing of CIN - Increase in SCr within 1–2 days because of decrease GFR
- Peak at 3–4 days after CM administration
CIN, contrast-induced nephropathy
Morcos SK.
In: Textbook of Contrast Media. 1999:135-148. Implications of CIN CIN may result in any or all of the following: - Delay in discharge of patient
- Permanent kidney damage
- Dialysis
- Increased patient mortality
CIN, contrast-induced nephropathy; CKD, chronic kidney disease Dangas G et al.
Am J Cardiol. 2005;95:13-19.
Prevention Strategies - Hydrate to a target urine output of 150 mL/h in the 6 hours postprocedure
- Avoid nephrotoxic drugs. Use prophylactic pharmacologic agents or procedures (eg, NAC, statins, ascorbic acid, hemofiltration)?
- Minimize volume of CM
- Consider choice of CM
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