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- “Contrast-enhanced dual-energy multidetector CT with material density analysis allows differentiation between adrenal adenomas and nonadenomas, reflecting an improved ability over nonenhanced multidetector CT for diagnosis of lipid-poor adenoma.”
Dual-Energy Multidetector CT for the Characterization of Incidental Adrenal Nodules: Diagnostic Performance of Contrast-enhanced Material Density Analysis.
Mileto A, Nelson RC, Marin D, Roy Choudhury K, Ho LM
Radiology. 2015 Feb;274(2):445-54 - “For diagnosis of adenomas, dual-energy material density analysis showed a sensitivity of 96% (23 of 24 lesions) at a specificity of 100% (23 of 23 lesions), yielding significantly improved diagnostic performance compared with nonenhanced multidetector CT attenuation (sensitivity of 67% [16 of 24 lesions] at a specificity of 100% [23 of 23 lesions]) (P = .035).”
Dual-Energy Multidetector CT for the Characterization of Incidental Adrenal Nodules: Diagnostic Performance of Contrast-enhanced Material Density Analysis.
Mileto A, Nelson RC, Marin D, Roy Choudhury K, Ho LM
Radiology. 2015 Feb;274(2):445-54 - “Compared with nonenhanced multidetector CT, contrast-enhanced dual-energy material density analysis has the potential to improve the diagnosis of lipid-poor adrenal adenomas, potentially eliminating the need for additional diagnostic work-up.”
Dual-Energy Multidetector CT for the Characterization of Incidental Adrenal Nodules: Diagnostic Performance of Contrast-enhanced Material Density Analysis.
Mileto A, Nelson RC, Marin D, Roy Choudhury K, Ho LM
Radiology. 2015 Feb;274(2):445-54
"With a decrease in attenuation at 80 kVp as an indicator of intracellular lipid within an adenoma, dual energy has 50% sensitivity, 100% specificity, 100% positive predictive value, and 28% negative predictive value in the diagnosis of adenoma."
Dual-Energy CT for Characterization of Adrenal Nodules: Initial Experience
Gupta RT et al.
AJR 2010; 1941479-1483"The mean attenuation change between 140 kVp and 80 kVp was 0.4 ± 7.1 HU for adenomas and 9.2 ± 4.3 HU for metastatic lesions. Fifty percent of adenomas had an attenuation decrease at 80 kVp. All metastatic lesions had an attenuation increase at 80 kVp. With a decrease in attenuation at 80 kVp as an indicator of intracellular lipid within an adenoma, dual energy has 50% sensitivity, 100% specificity, 100% positive predictive value, and 28% negative predictive value in the diagnosis of adenoma."
Dual-Energy CT for Characterization of Adrenal Nodules: Initial Experience
Gupta RT et al.
AJR 2010; 1941479-1483"A decrease in attenuation of an adrenal lesion between 140 kVp and 80 kVp is a highly specific sign of an adrenal adenoma. However, because an increase in attenuation at 80 kVp is seen with metastatic lesions and some adenomas, the sensitivity of this test is low. These data suggest that dual-energy CT can be used to help differentiate some lipid poor adrenal adenomas from metastatic lesions."
Dual-Energy CT for Characterization of Adrenal Nodules: Initial Experience
Gupta RT et al.
AJR 2010; 1941479-1483"With a decrease in attenuation at 80 kVp as an indicator of intracellular lipid within an adenoma, dual energy has 50% sensitivity, 100% specificity, 100% positive predictive value, and 28% negative predictive value in the diagnosis of adenoma."
Dual-Energy CT for Characterization of Adrenal Nodules: Initial Experience
Gupta RT et al.
AJR 2010; 1941479-1483