Imaging Pearls ❯ Chest ❯ Lymphoma
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- “The following parenchymal patterns were observed: 11 patients with single/multiple nodules, five with masses/mass-like consolidations, 14 with consolidations with air bronchogram, 16 with ground-glass opacity, ten with angiogram sign, 22 with perilymphatic and/or peribronchovascular spread, 15 with associated lymphadenopathies, and 13 with pleural/chest wall involvement. The main characteristics of PPLs were the presence of consolidations and ground-glass opacities, with perilymphatic and/or bronchovascular spread.”
Primary pulmonary lymphoma: imaging findings in 30 cases.
Cozzi, D et al.
Radiol med 124, 1262–1269 (2019). - “Lymphoproliferative pulmonary neoplasms can occur as primary pulmonary lymphomas or because of secondary pulmonary involvement. Neoplastic disorders may be difficult to differentiate from reactive pulmonary lymphoproliferative disorders, and immunohistochemical evaluation is often required to differentiate the 2 types of lesions. Neoplastic lymphoproliferative disorders are monoclonal lesions. Most affected patients present with systemic complaints, and imaging findings typically include nodules, masses, and lymphadenopathy.”
Lymphoproliferative Lung Disorders: A Radiologic-Pathologic Overview. Part II: Neoplastic Disorders,
Carlos S. Restrepo et al.
Seminars in Ultrasound, CT and MRI,Volume 34, Issue 6,2013 Pages 535-549, - "Primary pulmonary lymphomas are rare and account for less than 4% of the lymphomas that arise in extranodal sites. Secondary pulmonary lymphomas can affect the lung via hematogenous dissemination or by secondary involvement from tumor in adjacent or contiguous sites. Neoplastic lymphoproliferative lesions also include leukemia and plasma cell neoplasms. Posttransplantation lymphoproliferative disorders constitute a special type of lymphoid proliferation occurring in the setting of the chronic immunosuppression required for solid organ and bone marrow transplantation.”
Lymphoproliferative Lung Disorders: A Radiologic-Pathologic Overview. Part II: Neoplastic Disorders,
Carlos S. Restrepo et al.
Seminars in Ultrasound, CT and MRI,Volume 34, Issue 6,2013 Pages 535-549, - "Pulmonary lymphoma can occur either as a primary or as a secondary lesion. PPL is defined as a clonal lymphoid proliferation affecting the lung in a patient with no detectable extrapulmonary involvement by lymphoma at the time of diagnosis or during the 3 months following initial diagnosis. Secondary pulmonary lymphoma may affect the lung by either hematogenous dissemination from an extrapulmonary site of involvement or contiguous invasion by lymphoma affecting hilar or mediastinal lymph nodes.”
Lymphoproliferative Lung Disorders: A Radiologic-Pathologic Overview. Part II: Neoplastic Disorders,
Carlos S. Restrepo et al.
Seminars in Ultrasound, CT and MRI,Volume 34, Issue 6,2013 Pages 535-549, - "PPLs of the lung are defined as monoclonal lymphoid proliferations affecting one or both lungs (parenchyma bronchi or both) in a patient with no detectable extrapulmonary involvement at the time of diagnosis or during the subsequent 3 months. Exceptions to these criteria have been proposed to include cases in which the lung is the principal site of involvement in the setting of multifocal mucosa-associated lymphoid tissue (MALT) lymphoma.6 PPLs are B-cell non-Hodgkin's type in most of the cases. These neoplasms represent 3%-4% of extranodal lymphomas, but only 0.5%-1% of primary lung malignancies. Many PPLs are of low histologic grade and can be difficult to differentiate from reactive processes. Primary pulmonary Hodgkin's lymphoma (HL) has been described but is extremely rare.”
Lymphoproliferative Lung Disorders: A Radiologic-Pathologic Overview. Part II: Neoplastic Disorders,
Carlos S. Restrepo et al.
Seminars in Ultrasound, CT and MRI,Volume 34, Issue 6,2013 Pages 535-549, - "Intravascular large B-cell lymphoma (intravascular lymphomatosis) is rare. It is a disseminated large B-cell lymphoma that typically forms aggregates of lymphoma cells within vessels (including capillaries, venules, and arterioles) and lymph nodes. The initial lesion of affected patients typically occurs in the brain, but the lung is affected in 60% of these individuals. In addition, the skin and kidney are regularly involved. Symptoms include hypoxemia, dyspnea, and fever. Pulmonary involvement often manifests with reticulonodular opacities. There is typically no mediastinal lymph node involvement..
Lymphoproliferative Lung Disorders: A Radiologic-Pathologic Overview. Part II: Neoplastic Disorders,
Carlos S. Restrepo et al.
Seminars in Ultrasound, CT and MRI,Volume 34, Issue 6,2013 Pages 535-549,