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Everything you need to know about Computed Tomography (CT) & CT Scanning

Syndromes in CT: Men Imaging Pearls - Educational Tools | CT Scanning | CT Imaging | CT Scan Protocols - CTisus
Imaging Pearls ❯ Syndromes in CT ❯ MEN

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  • OBJECTIVE. Multiple endocrine neoplasia (MEN) syndromes are autosomal-dominant genetic disorders that predispose two or more organs of the endocrine system to tumor develop- ment. Although the diagnosis relies on clinical and serologic findings, imaging provides criti- cal information for surgical management with the ultimate goal of complete tumor resection.
    CONCLUSION. This article reviews abdominal neoplasms associated with the various subtypes of MEN syndromes, with a focus on clinical presentation and characteristic imaging features.
    Multiple Endocrine Neoplasia: Spectrum of Abdominal Manifestations
    Davila A et al.
    AJR 2020; 215:885–895
  • “Two major subtypes of MEN are recognized, MEN type 1 (MEN 1) and MEN type 2 (MEN 2), which is further subdivided into MEN type 2A (MEN 2A, or Sipple syndrome), and MEN type 2B (MEN 2B, or Wermer syndrome). Previously, MEN 2B and MEN 3 were interchangeable descriptions; however, the MEN 3 designation is no longer used. MEN 4, a relatively new sub- type, has features of MEN 1 but contains a genetically unrelated mutation.”
    Multiple Endocrine Neoplasia: Spectrum of Abdominal Manifestations
    Davila A et al.
    AJR 2020; 215:885–895
  • “At-risk patients have a greater probability for neoplasm development and should undergo screening. For MEN 1, these include patients with two or more MEN 1–associated tumors, a patient younger than 30 with a single MEN 1–associated tumor, or a patient with a family member diagnosed with MEN 1. For MEN 2, these include patients with medullary thyroid cancer, two or more MEN 2–associated tumors, a single MEN 2–associated tumor in a patient less than 30, a patient with clinical or phenotypic features of MEN 2, or a family member of a patient with a diagnosis of MEN 2.”
    Multiple Endocrine Neoplasia: Spectrum of Abdominal Manifestations
    Davila A et al.
    AJR 2020; 215:885–895
  • "The main components of MEN 1 include parathyroid, pancreatic, and pituitary tumors caused by an autosomal-dominant germ- line mutation involving the tumor suppres- sor gene, MEN1. MEN 1 has a prevalence of 2–20 per 100,000 patients with an approxi- mate incidence in randomly selected autopsy cases of 0.2%.”
    Multiple Endocrine Neoplasia: Spectrum of Abdominal Manifestations
    Davila A et al.
    AJR 2020; 215:885–895
  • "Multiple endocrine neoplasia is a diverse group of syndromes with abdominal manifestations that require correlation with laboratory testing, clinical examination findings, and imaging for diagnosis. Specific imaging protocols are necessary for accurate detection of tumors because MEN syndromes can be silent, with lesions discovered only incidentally. Radiologists thus play an essential role in the early detection and follow-up of patients with the various MEN syndromes.”
    Multiple Endocrine Neoplasia: Spectrum of Abdominal Manifestations
    Davila A et al.
    AJR 2020; 215:885–895
© 1999-2020 Elliot K. Fishman, MD, FACR. All rights reserved.