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Everything you need to know about Computed Tomography (CT) & CT Scanning

State-of-the-art Diagnosis and Treatment of Metastatic Melanoma: MDCT Protocol Optimization to Identify Metastases in Unusual Locations and Review of Innovative Therapeutic Agents

CT in Melanoma: Past to Future

  • CT alters management in melanoma by simply detecting metastases34.
  • Therapy response assessment with CT
    • Changes in lesion density on CT as evidence of treatment response (not yet proven to correlate with survival)35
    • “Halo sign” of ground-glass attenuation surrounding pulmonary metastasis after adoptive cell therapy correlates with response36
  • In combination with other modalities
    • Targeted radiotracers for both imaging and therapy37
      • Very late antigen-4 (VLA-4; integrin α4β1) promotes adhesion and migration of melanoma cells
      • A high affinity peptidomimetic ligand (LLP2A) targets VLA-4
      • Conjugate with 68Ga allows PET/CT imaging, while conjugate with 177Lu allows therapy and monitoring with SPECT/CT
    • Targeted palliative therapy for liver metastases with chemoembolization (irinotecan drug-eluting beads) 38 and radioembolization39

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