Medical digital twins: enabling precision medicine and medical artificial intelligence
Christoph Sadée, Stefano Testa, Thomas Barba, Katherine Hartmann, Maximilian Schuessler, Alexander Thieme, George M Church, Ifeoma Okoye, Tina Hernandez-Boussard, Leroy Hood, Ilya Shmulevich, Ellen Kuhl, Olivier Gevaert
Lancet Digit Health. 2025 Jun 14:100864. doi: 10.1016/j.landig.2025.02.004. Online ahead of print.
Abstract
The notion of medical digital twins is gaining popularity both within the scientific community and among the general public; however, much of the recent enthusiasm has occurred in the absence of a consensus on their fundamental make-up. Digital twins originate in the field of engineering, in which a constantly updating virtual copy enables analysis, simulation, and prediction of a real-world object or process. In this Health Policy paper, we evaluate this concept in the context of medicine and outline five key components of the medical digital twin: the patient, data connection, patient-in-silico, interface, and twin synchronisation. We consider how various enabling technologies in multimodal data, artificial intelligence, and mechanistic modelling will pave the way for clinical adoption and provide examples pertaining to oncology and diabetes. We highlight the role of data fusion and the potential of merging artificial intelligence and mechanistic modelling to address the limitations of either the AI or the mechanistic modelling approach used independently. In particular, we highlight how the digital twin concept can support the performance of large language models applied in medicine and its potential to address health-care challenges. We believe that this Health Policy paper will help to guide scientists, clinicians, and policy makers in creating medical digital twins in the future and translating this promising new paradigm from theory into clinical practice.