Vaibhav Jain, Jitesh Ahuja, Chad D Strange, Rishi Agrawal, Diana M Palacio, Mylene T Truong, Edith M Marom
Radiol Clin North Am. 2025 Jul;63(4):609-631. doi: 10.1016/j.rcl.2024.12.006. Epub 2025 Jan 24.
A diverse group of conditions can present as a mediastinal mass, posing a diagnostic challenge for radiologists. As a first step toward an accurate diagnosis, precise localization of the mass to the appropriate compartment, followed by the assessment of its internal characteristics is important. The classification proposed by the International Thymic Malignancy Interest Group is the current practice standard for localizing mediastinal masses. Computed tomography remains the most widely used imaging modality for their diagnosis with an increasing use of MR imaging to problem solve owing to its superior tissue contrast and ability to characterize different tissue types.