T Thanya, T Jeslin
Abdom Radiol (NY). 2025 Mar 6. doi: 10.1007/s00261-025-04860-9. Online ahead of print.
Computed Tomography (CT) imaging captures detailed cross-sectional images of the pancreas and surrounding structures and provides valuable information for medical professionals. The classification of pancreatic CT images presents significant challenges due to the complexities of pancreatic diseases, especially pancreatic cancer. These challenges include subtle variations in tumor characteristics, irregular tumor shapes, and intricate imaging features that hinder accurate and early diagnosis. Image noise and variations in image quality also complicate the analysis. To address these classification problems, advanced medical imaging techniques, optimization algorithms, and deep learning methodologies are often employed. This paper proposes a robust classification model called DeepOptimalNet, which integrates optimization algorithms and deep learning techniques to handle the variability in imaging characteristics and subtle variations associated with pancreatic tumors. The model uses a comprehensive approach to enhance the analysis of medical CT images, beginning with the application of the Gaussian smoothing filter (GSF) for noise reduction and feature enhancement. It introduces the Modified Remora Optimization Algorithm (MROA) to improve the accuracy and efficiency of pancreatic cancer tissue segmentation. The adaptability of modified optimization algorithms to specific challenges such as irregular tumor shapes is emphasized. The paper also utilizes Deep Transfer CNN with ResNet-50 (DTCNN) for feature extraction, leveraging transfer learning to enhance prediction accuracy in CT images. ResNet-50's strong feature extraction capabilities are particularly relevant to fault diagnosis in CT images. The focus then shifts to a Deep Cascade Convolutional Neural Network with Multimodal Learning (DCCNN-ML) for classifying pancreatic cancer in CT images. The DeepOptimalNet approach underscores the advantages of deep learning techniques, multimodal learning, and cascade architectures in addressing the complexity and subtle variations inherent in pancreatic cancer imaging, ultimately leading to more accurate and robust classifications. The proposed DeepOptimalNet achieves 99.3% accuracy, 99.1% sensitivity, 99.5% specificity, and 99.3% F-score, surpassing existing models in pancreatic tumor classification. Its MROA-based segmentation improves boundary delineation, while DTCNN with ResNet-50 enhances feature extraction for small and low-contrast tumors. Benchmark validation confirms its superior classification performance, reduced false positives, and improved diagnostic reliability compared to traditional deep learning methods.