Emerging and extensive clonal evolution in the pancreas

Alvin P Makohon-Moore

Trends Cancer . 2024 Jul 7:S2405-8033(24)00137-7. doi: 10.1016/j.trecan.2024.06.011. Online ahead of print.

Abstract

Pancreatic cancer is one of the most lethal malignancies, yet much remains to be learned regarding how its precursors develop. In a recent Nature publication, Braxton and Kiemen et al. found that the normal, adult pancreas harbors hundreds to thousands of pancreatic cancer precursors evolving by a variety of routes.