Cancer of unknown primary sites: what radiologists need to know and what oncologists want to know.

AJR Am J Roentgenol. 2013 Mar;200(3):484-92. doi: 10.2214/AJR.12.9363.
Kim KW, Krajewski KM, Jagannathan JP, Nishino M, Shinagare AB, Hornick JL, Ramaiya NH.
Source
Department of Imaging, Dana-Farber Cancer Institute, Harvard Medical School, 450 Brookline Ave, Boston, MA, 02215.
Abstract
OBJECTIVE: In this article, we review the role of imaging in cancer of unknown primary site (CUP) diagnosis and management and the utility of immunohistochemistry, serum tumor markers, and molecular profiling in the optimized care of CUP patients. CONCLUSION: With advances in imaging, pathology, and molecular medicine, the diagnosis and management of CUP have evolved into more personalized and site-specific therapies. A multidisciplinary integrated approach among oncologists, pathologists, and radiologists is extremely important.