Coronary computed tomographic angiography is leading a technologic revolution in the field of cardiac imaging. For the first time, it is possible to image the wall of the coronary artery noninvasively to assess plaque burden, characterize plaque, and assess the degree of stenosis. This paper explores the possibility of using coronary computed tomographic angiography as a screening tool. Key screening examination elements, the pros and cons of screening, the limitations of current technology, and potential pitfalls are discussed.