CT has traditionally played a valuable role in the detection and staging of pancreatic cancer. The critical goal in imaging patients with pancreatic cancer is to determine potential resectability. As we discussed in the preceding article, arterial involvement will render the patient ineligible for curative resection. In addition, tumor involvement of key venous structures signifies surgically unresectable disease. The purpose of this pictorial essay is to show the unique capabilities of multidetector CT angiography in the evaluation of key venous structures and its value in imaging patients with suspected or known pancreatic cancer. Involvement of arterial structures is described in the companion article.