Deep venous thrombosis (DVT) and pulmonary embolism are described as two aspects of the same continuum�venopulmonary thromboembolic disease, which results in significant morbidity and mortality [1]. Recent studies [1-6] have found that a combination of helical CT angiography of pulmonary arteries and indirect CT venography of lower limbs allows a complete one-session evaluation of venopulmonary thromboembolism. Sensitivities of 89-100% and specificities of 94-100% have been reported and compared with sonography [3, 4, 6]. Nevertheless, detection of an acute clot with CT venography requires optimal selection of technical parameters, knowledge of venous anatomy and common variants, and knowledge of CT signs reflecting DVT. The radiologist should also be aware of interpretative difficulties inherent to the CT examination of limb veins. We review the practical approach to DVT with CT venography on the basis of our experience with more than 800 combined examinations.