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- “Contrast-enhanced dual-energy multidetector CT with material density analysis allows differentiation between adrenal adenomas and nonadenomas, reflecting an improved ability over nonenhanced multidetector CT for diagnosis of lipid-poor adenoma.”
Dual-Energy Multidetector CT for the Characterization of Incidental Adrenal Nodules: Diagnostic Performance of Contrast-enhanced Material Density Analysis.
Mileto A, Nelson RC, Marin D, Roy Choudhury K, Ho LM
Radiology. 2015 Feb;274(2):445-54 - “For diagnosis of adenomas, dual-energy material density analysis showed a sensitivity of 96% (23 of 24 lesions) at a specificity of 100% (23 of 23 lesions), yielding significantly improved diagnostic performance compared with nonenhanced multidetector CT attenuation (sensitivity of 67% [16 of 24 lesions] at a specificity of 100% [23 of 23 lesions]) (P = .035).”
Dual-Energy Multidetector CT for the Characterization of Incidental Adrenal Nodules: Diagnostic Performance of Contrast-enhanced Material Density Analysis.
Mileto A, Nelson RC, Marin D, Roy Choudhury K, Ho LM
Radiology. 2015 Feb;274(2):445-54 - “Compared with nonenhanced multidetector CT, contrast-enhanced dual-energy material density analysis has the potential to improve the diagnosis of lipid-poor adrenal adenomas, potentially eliminating the need for additional diagnostic work-up.”
Dual-Energy Multidetector CT for the Characterization of Incidental Adrenal Nodules: Diagnostic Performance of Contrast-enhanced Material Density Analysis.
Mileto A, Nelson RC, Marin D, Roy Choudhury K, Ho LM
Radiology. 2015 Feb;274(2):445-54
- “To determine whether contrast material-enhanced dual-energy multidetector computed tomography (CT) with material decomposition analysis allows differentiation of adrenal adenomas from nonadenomatous lesions and to compare findings with those of nonenhanced multidetector CT.”
Dual-Energy Multidetector CT for the Characterization of Incidental Adrenal Nodules: Diagnostic Performance of Contrast-enhanced Material Density Analysis
Mileto A et al.
Radiology. 2014 Sep 10:140876. [Epub ahead of print] - “Adenomas (lipid rich and lipid poor) displayed significantly different mean density values (in milligrams per cubic centimeter) than those of nonadenomas on fat-iodine (970.4 ± 17.2 vs 1012.3 ± 9.3), iodine-fat (2.5 ± 0.3 vs 4.5 ± 1.5), fat-water (-666.7 ± 154.8 vs -2141.8 ± 953.2), and water-fat (1628.4 ± 177.3 vs 3225 ± 986.1) images, respectively (P < .0001). For diagnosis of adenomas, dual-energy material density analysis showed a sensitivity of 96% (23 of 24 lesions) at a specificity of 100% (23 of 23 lesions), yielding significantly improved diagnostic performance compared with nonenhanced multidetector CT attenuation (sensitivity of 67% [16 of 24 lesions] at a specificity of 100% [23 of 23 lesions]) (P = .035).”
Dual-Energy Multidetector CT for the Characterization of Incidental Adrenal Nodules: Diagnostic Performance of Contrast-enhanced Material Density Analysis
Mileto A et al.
Radiology. 2014 Sep 10:140876. [Epub ahead of print] - “ For diagnosis of adenomas, dual-energy material density analysis showed a sensitivity of 96% (23 of 24 lesions) at a specificity of 100% (23 of 23 lesions), yielding significantly improved diagnostic performance compared with nonenhanced multidetector CT attenuation (sensitivity of 67% [16 of 24 lesions] at a specificity of 100% [23 of 23 lesions]) (P = .035).”
Dual-Energy Multidetector CT for the Characterization of Incidental Adrenal Nodules: Diagnostic Performance of Contrast-enhanced Material Density Analysis
Mileto A et al.
Radiology. 2014 Sep 10:140876. [Epub ahead of print] - “Contrast-enhanced dual-energy multidetector CT with material density analysis allows differentiation between adrenal adenomas and nonadenomas, reflecting an improved ability over nonenhanced multidetector CT for diagnosis of lipid-poor adenoma.”
Dual-Energy Multidetector CT for the Characterization of Incidental Adrenal Nodules: Diagnostic Performance of Contrast-enhanced Material Density Analysis
Mileto A et al.
Radiology. 2014 Sep 10:140876. [Epub ahead of print]
- “ Reconstruction of virtual unenhanced images from contrast-enhanced dual energy CT of the abdomen allows the characterization of the incidental adrenal masses with a good accuracy compared with standard unenhanced CT, with the most favorable results in incidental adrenal masses measuring ≥1 cm.”
Dual-Energy CT for Characterization of the Incidental Adrenal Mass: Preliminary Observations
Gnannt R et al.
AJR 2012; 198:138-144
"With a decrease in attenuation at 80 kVp as an indicator of intracellular lipid within an adenoma, dual energy has 50% sensitivity, 100% specificity, 100% positive predictive value, and 28% negative predictive value in the diagnosis of adenoma."
Dual-Energy CT for Characterization of Adrenal Nodules: Initial Experience
Gupta RT et al.
AJR 2010; 1941479-1483"The mean attenuation change between 140 kVp and 80 kVp was 0.4 ± 7.1 HU for adenomas and 9.2 ± 4.3 HU for metastatic lesions. Fifty percent of adenomas had an attenuation decrease at 80 kVp. All metastatic lesions had an attenuation increase at 80 kVp. With a decrease in attenuation at 80 kVp as an indicator of intracellular lipid within an adenoma, dual energy has 50% sensitivity, 100% specificity, 100% positive predictive value, and 28% negative predictive value in the diagnosis of adenoma."
Dual-Energy CT for Characterization of Adrenal Nodules: Initial Experience
Gupta RT et al.
AJR 2010; 1941479-1483"A decrease in attenuation of an adrenal lesion between 140 kVp and 80 kVp is a highly specific sign of an adrenal adenoma. However, because an increase in attenuation at 80 kVp is seen with metastatic lesions and some adenomas, the sensitivity of this test is low."
Dual-Energy CT for Characterization of Adrenal Nodules: Initial Experience
Gupta RT et al.
AJR 2010; 1941479-1483