Frederick Thurston Drake, Sabrina E Sanchez
JAMA Surg . 2024 Apr 17. doi: 10.1001/jamasurg.2023.5946. Online ahead of print.
The Appendicitis Acuta II (APPAC II) trial was a rigorous noninferiority randomized clinical trial that compared the effectiveness of oral antibiotics alone vs a combination of intravenous and oral antibiotics for the initial management of uncomplicated acute appendicitis.